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醫(yī)藥網(wǎng)1月27日訊　1月21日，國家藥監(jiān)局官網(wǎng)顯示，鹽酸右美托咪定注射液有宜昌人福藥業(yè)、湖南科倫制藥、成都倍特藥業(yè)等5家企業(yè)以補充申請獲批過評；鹽酸右美托咪定氯化鈉注射液江蘇恒瑞醫(yī)藥首仿獲批。在此之前，江蘇恒瑞醫(yī)藥的鹽酸右美托咪定注射液也以補充申請獲批過評。米內(nèi)網(wǎng)數(shù)據(jù)顯示，2020年前三季度重點省市公立醫(yī)院終端神經(jīng)系統(tǒng)化藥市場增速同比下滑18.25%。 </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;"> </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;"> TOP10廠家中，有揚子江藥業(yè)集團、宜昌人福藥業(yè)、齊魯制藥、江蘇恩華藥業(yè)、江蘇恒瑞醫(yī)藥5家國內(nèi)企業(yè)。產(chǎn)品TOP10中，有8個是注射劑。品牌TOP10中，10億大品種僅有揚子江藥業(yè)集團的地佐辛注射液，而集采則“帶飛”鹽酸右美托咪定注射液成為第二大品牌；江蘇恒瑞醫(yī)藥的獨家產(chǎn)品酒石酸布托啡諾注射液市場份額不斷提升，躍升至第六位。 </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;"> </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;"> <strong> 神經(jīng)系統(tǒng)化藥再掀風(fēng)暴！廣東成銷售“大戶”，四大亞類合攬八成市場</strong> </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;"> </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;"> 1月21日，國家藥監(jiān)局官網(wǎng)顯示，鹽酸右美托咪定注射液有宜昌人福藥業(yè)、湖南科倫制藥、成都倍特藥業(yè)等5家企業(yè)以補充申請獲批過評；鹽酸右美托咪定氯化鈉注射液江蘇恒瑞醫(yī)藥首仿獲批。在此之前，江蘇恒瑞醫(yī)藥的鹽酸右美托咪定注射液也以補充申請獲批過評；揚子江藥業(yè)集團的丙泊酚中/長鏈脂肪乳注射液以仿制4類獲批上市，該產(chǎn)品已被納入第四批國家集采……在一系列“動作”的背后，神經(jīng)系統(tǒng)化藥市場或再掀風(fēng)暴。 </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;"> </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;text-align:center;"> 近年重點省市公立醫(yī)院終端神經(jīng)系統(tǒng)化藥銷售情況（單位：億元） </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;text-align:center;"> <img alt="" src="http://www.pharmnet.com.cn/image/upload/images/20210127091030.png" style="margin:0px;padding:0px;list-style-type:none;height:286px;width:550px;" /> </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;text-align:center;"> 來源：米內(nèi)網(wǎng)重點省市公立醫(yī)院終端競爭格局 </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;"> </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;"> 米內(nèi)網(wǎng)數(shù)據(jù)顯示，近年重點省市公立醫(yī)院終端神經(jīng)系統(tǒng)化藥市場增速放緩，2020年前三季度雖然同比下滑18.25%，但銷售額仍超過100億元規(guī)模。從季度銷售趨勢來看，第一季度同比下滑超過35%，第二季度同比下滑14%，第三季度同比下滑不足5%，市場逐步回暖。 </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;"> </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;text-align:center;"> 近年重點省市公立醫(yī)院終端神經(jīng)系統(tǒng)化藥城市格局（單位：億元） </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;text-align:center;"> <img alt="" src="http://www.pharmnet.com.cn/image/upload/images/20210127091046.png" style="margin:0px;padding:0px;list-style-type:none;height:251px;width:550px;" /> </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;text-align:center;"> 來源：米內(nèi)網(wǎng)重點省市公立醫(yī)院終端競爭格局 </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;"> </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;"> 從城市格局來看，廣東、上海、江蘇、北京、山東5個省市銷售規(guī)模均超過10億元，而廣東一枝獨秀，超過15億元。TOP10廠家中，有揚子江藥業(yè)集團、宜昌人福藥業(yè)、齊魯制藥、江蘇恩華藥業(yè)、江蘇恒瑞醫(yī)藥5家國內(nèi)企業(yè)，其中，揚子江藥業(yè)集團增速最快，超過15%。從亞類格局來看，精神興奮藥、止痛藥、麻醉劑、精神安定藥是四大主要亞類，合計市場份額占比超過80%。從劑型來看，注射劑和片劑是兩大主流劑型，合計市場份額占比接近90%，而余下的市場份額則是由膠囊劑、吸入劑等劑型瓜分。 </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;"> </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;"> <strong> 8大注射劑搶占TOP10！揚子江領(lǐng)軍，人福重磅品種過評，恒瑞獨家產(chǎn)品亮眼</strong> </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;"> </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;text-align:center;"> <strong> </strong> 重點省市公立醫(yī)院終端神經(jīng)系統(tǒng)化藥產(chǎn)品TOP10 </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;text-align:center;"> <img alt="" src="http://www.pharmnet.com.cn/image/upload/images/20210127091104.png" style="margin:0px;padding:0px;list-style-type:none;height:302px;width:398px;" /> </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;text-align:center;"> 來源：米內(nèi)網(wǎng)重點省市公立醫(yī)院終端競爭格局 </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;"> </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;"> 產(chǎn)品TOP10市場份額合計占神經(jīng)系統(tǒng)化藥比例近35%。從劑型來看，除了吸入用七氟烷和奧氮平片外，8個均是注射劑。 </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;"> </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;text-align:center;"> 2020Q1-Q3重點省市公立醫(yī)院終端神經(jīng)系統(tǒng)化<strong><a target="_blank" style="color:#333333;text-decoration-line:none;"><span style="color:#009966;">藥品</span></a></strong>牌TOP10 </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;text-align:center;"> <strong><img alt="" src="http://www.pharmnet.com.cn/image/upload/images/20210127091122.png" style="margin:0px;padding:0px;list-style-type:none;height:280px;width:422px;" /></strong> </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;text-align:center;"> 來源：米內(nèi)網(wǎng)重點省市公立醫(yī)院終端競爭格局 </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;"> </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;"> 品牌TOP10中，除了費森尤斯卡比的丙泊酚中/長鏈脂肪乳注射液、Aspen的丙泊酚乳狀注射液、NAPP的鹽酸羥考酮緩釋片外，國內(nèi)藥企占據(jù)7個席位。其中，10億大品種僅有揚子江藥業(yè)集團的地佐辛注射液，而集采則“帶飛”鹽酸右美托咪定注射液成為第二大品牌；江蘇恒瑞<strong><a target="_blank" style="color:#333333;text-decoration-line:none;"><span style="color:#009966;">醫(yī)藥</span></a></strong>的獨家產(chǎn)品酒石酸布托啡諾注射液市場份額不斷提升，躍升至第六位。 </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;"> </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;text-align:center;"> 近年重點省市公立醫(yī)院終端地佐辛注射劑銷售情況（單位：億元） </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;text-align:center;"> <img alt="" src="http://www.pharmnet.com.cn/image/upload/images/20210127091138.png" style="margin:0px;padding:0px;list-style-type:none;height:286px;width:550px;" /> </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;text-align:center;"> 來源：米內(nèi)網(wǎng)重點省市公立醫(yī)院終端競爭格局 </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;"> </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;"> 地佐辛由Wyeth-Ayerst實驗室研發(fā)，適應(yīng)癥為需要使用阿片類鎮(zhèn)痛藥治療的各種疼痛。米內(nèi)網(wǎng)數(shù)據(jù)顯示，近年在重點省市公立醫(yī)院終端地佐辛注射劑銷售額屢創(chuàng)新高，2019年突破20億大關(guān)。地佐辛注射液僅有揚子江藥業(yè)集團和南京優(yōu)科制藥兩家生產(chǎn)<strong><a target="_blank" style="color:#333333;text-decoration-line:none;"><span style="color:#009966;">企業(yè)</span></a></strong>，其中，揚子江藥業(yè)集團的市場份額一枝獨秀，而南京優(yōu)科制藥在2019年底獲批，銷售規(guī)模較小。目前該產(chǎn)品沒有企業(yè)過評，恩華藥業(yè)、天津藥物研究院以新分類提交上市申請在審評審批中（在藥審中心），獲批后將視同過評。 </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;"> </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;"> 鹽酸右美托咪定注射液由Oricon Pharma與雅培公司聯(lián)合研發(fā)，1999年在美國獲批上市，后續(xù)分別在歐盟、日本等多個國家和地區(qū)上市銷售，2009年江蘇恒瑞醫(yī)藥在國內(nèi)首家上市。米內(nèi)網(wǎng)數(shù)據(jù)顯示，近年重點省市公立<strong><a target="_blank" style="color:#333333;text-decoration-line:none;"><span style="color:#009966;">醫(yī)院</span></a></strong>終端右美托咪定注射劑銷售額穩(wěn)步增長，2020年前三季度同比稍有下滑。鹽酸右美托咪定注射液競爭激烈，目前生產(chǎn)企業(yè)有江蘇恒瑞醫(yī)藥、揚子江藥業(yè)集團、宜昌人福藥業(yè)、湖南科倫制藥等11家，其中，揚子江藥業(yè)集團、國藥集團工業(yè)、江蘇恒瑞醫(yī)藥、湖南科倫制藥等8家企業(yè)過評。此外，江蘇華泰晨光藥業(yè)、辰欣藥業(yè)等3家企業(yè)的一致性評價補充申請在審評審批中（在藥審中心），江蘇正大清江制藥、石家莊四藥、南京正大天晴制藥等6家企業(yè)以仿制3類報產(chǎn)在審評審批中（在藥審中心），獲批后視同過評。資料顯示，2018年6月，揚子江藥業(yè)集團的鹽酸右美托咪定注射液以3類仿制獲批上市，并視同過評，隨后獨家中標4+7和聯(lián)盟地區(qū)集采，市場份額從2018年不足1%增長至2020年前三季度近90%，銷售額同比增長近200%。 </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;"> </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;text-align:center;"> 近年重點省市公立醫(yī)院終端布托啡諾注射劑銷售情況（單位：億元） </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;text-align:center;"> <img alt="" src="http://www.pharmnet.com.cn/image/upload/images/20210127091222.png" style="margin:0px;padding:0px;list-style-type:none;height:286px;width:550px;" /> </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;text-align:center;"> 來源：米內(nèi)網(wǎng)重點省市公立醫(yī)院終端競爭格局 </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;"> </div> <div style="margin:0px;padding:0px;border:0px;list-style-type:none;overflow:visible;zoom:normal;color:#333333;font-family:normal;font-size:14px;white-space:normal;background-color:#F7F7F7;"> 酒石酸布托啡諾注射液是江蘇恒瑞醫(yī)藥的獨家產(chǎn)品。米內(nèi)網(wǎng)數(shù)據(jù)顯示，近年重點省市公立醫(yī)院終端布托啡諾注射劑銷售額快速增長，從2015年不足5000萬元增至2019年超過4億元。目前，酒石酸布托啡諾注射液生產(chǎn)企業(yè)僅有江蘇恒瑞醫(yī)藥，國藥集團國瑞藥業(yè)的酒石酸布托啡諾注射液以仿制3類報產(chǎn)在審評審批中（在藥審中心）。 </div> <div 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